Gliclazide belongs to a group of medicines called sulfonylureas that are used to lower the blood sugar level.
Gliclazide is used in the treatment of diabetes mellitus when diet, physical exercise and weight loss alone fails to lower blood glucose (sugar). They are not for use in children or in patients with diabetes requiring insulin.
Do not take Gliclazide and tell your doctor if you:
-are allergic to gliclazide or any of the other ingredients of this medicine, to other medicines of the same group (sulfonylureas), to other related medicines (hypoglycaemic sulfonamides)
-have insulin-dependent diabetes (type 1)
-have ketone bodies and sugar in your urine (this may mean you have keto-acidosis), a diabetic pre-coma and coma
-have severe kidney or liver disease
During gliclazide treatment regular monitoring of your blood (and possibly urine) sugar level and also your glycated haemoglobin (HbA1c) is necessary.
In the first few weeks of treatment the risk of having reduced blood sugar levels (hypoglycaemia) may be increased. So particularly close medical monitoring is necessary.
Drinking alcohol is not recommended as it can alter the control of your diabetes.
Gliclazide is not recommended for use during pregnancy. If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
You must not take Gliclazide while you are breast-feeding.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
The blood sugar lowering effect of gliclazide may be strengthened and signs of low blood sugar levels may occur when one of the following medicines is taken:
-other medicines used to treat high blood sugar (oral antidiabetics, GLP-1 receptor inhibitors or insulin)
-antibiotics (e.g. sulfonamides, clarithromycin)
-medicines to treat high blood pressure or heart failure (beta blockers, ACE-inhibitors such as captopril or enalapril)
-medicines to treat fungal infections (miconazole, fluconazole)
-medicines to treat ulcers in the stomach or duodenum (H2 receptor antagonists)
-medicines to treat depression (monoamine oxidase inhibitors)
-painkiller or antirheumatics (phenylbutazone, ibuprofen)
-medicines containing alcohol.
-St John’s Wort (Hypericum perforatum) preparations
Blood glucose disturbance (low blood sugar and high blood sugar) can occur when a medicine belonging to a class of antibiotics called fluoroquinolones is taken at the same time as Gliclazide, especially in elderly patients.
The blood glucose lowering effect of gliclazide may be weakened and raised blood sugar levels may occur when one of the following medicines is taken:
-medicines to treat disorders of the central nervous system (chlorpromazine)
-medicines reducing inflammation (corticosteroids)
-medicines to treat asthma or used during labour (intravenous salbutamol, ritodrine and terbutaline)
-medicines to treat breast disorders, heavy menstrual bleeding and endometriosis (danazol).
Gliclazide may increase the effects of medicines which reduce blood clotting (e.g. warfarin).
Consult your doctor or pharmacist before you start taking another medicinal product. If you go into hospital tell the medical staff you are taking Gliclazide.
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
These tablets should be taken with a glass of water before meals.
The starting dose is usually 40-80mg once daily and may be increased to a total daily dose of 40-320mg. Do not take more than the maximum of 160mg as a single dose. For doses of 320mg this will be split over the day.
If a combination therapy of Gliclazide tablets with metformin, an alpha glucosidase inhibitor, a thiazolidinedione, a dipeptidyl peptidase-4 inhibitor, a GLP-1 receptor agonist or insulin is initiated, your doctor will determine the proper dose of each medicine individually for you.
lf you notice that your blood sugar levels are high although you are taking the medicine as prescribed, you should contact your doctor or pharmacist.
If you take too many tablets, contact your doctor or the nearest hospital Accident & Emergency department immediately. The signs of overdose are those of low blood sugar (hypoglycaemia) The symptoms can be helped by taking sugar (4 to 6 lumps) or sugary drinks straight away, followed by a substantial snack or meal. If the patient is unconscious, immediately inform a doctor and call the emergency services.
Take it as soon as you remember, unless it is nearly time for your next dose. Then carry on as before. Do not take a double dose to make up for a forgotten dose.
If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Like all medicines, this medicine can cause side effects although not everybody gets them.
The most commonly observed side effect is low blood sugar (hypoglycaemia). If left untreated these symptoms could progress to drowsiness, loss of consciousness or possibly coma. If an episode of low blood sugar is severe or prolonged, even if it is temporarily controlled by eating sugar, you should seek immediate medical attention
Other side effects
-Digestive disorders: Abdominal pain, nausea, vomiting, indigestion, diarrhoea and constipation. These effects are reduced when Gliclazide tablets are taken with a meal as recommended.
-Skin disorders: Skin reactions such as rash, redness, itching, hives, angioedema (rapid swelling of tissues such as eyelids, face, lips, mouth, tongue or throat that may result in breathing difficulty) have been reported. The rash may progress to widespread blistering or peeling of the skin.
Exceptionally, signs of severe hypersensitivity reactions (DRESS) have been reported: initially as flu-like symptoms and a rash on the face then an extended rash with a high temperature.
-Blood disorders: Decrease in the number of cells in the blood (e.g. platelets, red and white blood cells) which may cause paleness, prolonged bleeding, bruising, sore throat and fever. These symptoms usually stop when the treatment is discontinued.
-Liver disorders: There have been isolated reports of abnormal liver function which can cause yellow skin and eyes. If you get this, see your doctor immediately. The symptoms generally disappear if the drug is stopped. Your doctor will decide whether to stop your treatment.
-Eye disorders: Your vision may be affected for a short time, especially at the start of treatment. This effect is due to changes in blood sugar levels.
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed here.
If you have any questions about buying discount gliclazide (Diamicron) online or any other prescription products you can contact our team of professional Patient Service Representatives or one of our pharmacists by calling 1-833-313-3173.
Notice: The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.