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Duloxetine Hydrochloride
Sourced from United Kingdom
Prescription Required
Duloxetine Hydrochloride
Sourced from Canada
Prescription Required
Duloxetine Hydrochloride
Sourced from United Kingdom
Prescription Required
Generic Equivalents what's the difference?
Duloxetine (Generic)
Duloxetine Hydrochloride
Sourced from Canada
Prescription Required
Duloxetine (Generic)
Duloxetine Hydrochloride
Sourced from United Kingdom
Prescription Required

Duloxetine (Cymbalta, Irenka, Yentreve)

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). This medicine affects chemicals in the brain that may be unbalanced in people with depression.

Duloxetine is used to treat;

-major depressive disorder in adults,

-fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain),

-pain caused by nerve damage in adults with diabetes (diabetic neuropathy),

-general anxiety disorder in adults and children who are at least 7 years old.

YENTREVE is a hard gastro-resistant capsule. Each capsule of YENTREVE contains pellets of duloxetine hydrochloride with a covering to protect them from stomach acid. YENTREVE is used to treat Stress Urinary Incontinence (SUI) (accidental loss or leakage of urine during physical exertion) in women.

Duloxetine may also be used for other purposes not listed in this medication guide.

Important Information about Duloxetine (Cymbalta, Irenka, Yentreve)

You should not use duloxetine if you are allergic to it.

Duloxetine is not approved for use by anyone younger than 7 years old. YENTREVE should not be used for children and adolescents under 18 years.

Tell your doctor if you have ever had:

-liver or kidney disease;

-slow digestion;

-a seizure;

-bleeding problems;

-narrow-angle glaucoma;

-bipolar disorder (manic depression); or

-drug addiction or suicidal thoughts.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

YENTREVE may cause a sensation of restlessness or an inability to sit or stand still. You should tell your doctor if this happens to you.

Taking duloxetine during pregnancy may cause breathing problems, feeding problems, seizures, or other complications in the newborn baby. However, you may have a relapse of depression if you stop taking this medicine. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor’s advice.

It may not be safe to breast-feed while using this medicine. Therefore, ask your doctor about any risk.

How To Take Duloxetine (Cymbalta, Irenka, Yentreve)

Take duloxetine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Taking duloxetine in higher doses or more often than prescribed will not make it more effective, and may increase side effects.

Swallow the capsule whole and do not crush, chew, break, or open it.

You may take duloxetine with or without food.

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Have your blood pressure checked often.

Do not stop using this medicine suddenly, or you could have unpleasant symptoms (such as dizziness, nausea, diarrhea, irritability, or anxiety). Ask your doctor how to safely stop using this medicine.

Missed dose:

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


Seek emergency medical attention.


Store at room temperature away from moisture and heat.

Possible Side Effects of Duloxetine (Cymbalta, Irenka, Yentreve)

Get emergency medical help if you have signs of an allergic reaction to duloxetine (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

-pounding heartbeats or fluttering in your chest;

-a light-headed feeling, like you might pass out;

-easy bruising, unusual bleeding;

-vision changes;

-painful or difficult urination;

-impotence, sexual problems;

-liver problems – right-sided upper stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);

-low levels of sodium in the body – headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or

-a manic episode – racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common duloxetine side effects may include:


-nausea, constipation, loss of appetite;

-dry mouth; or

-increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What to avoid while taking Duloxetine (Cymbalta, Irenka, Yentreve)

Avoid driving or hazardous activity until you know how duloxetine will affect you (impaired reactions). Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or fainting can cause falls, accidents, or severe injuries.

Avoid drinking alcohol. It may increase your risk of liver damage.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with duloxetine may cause you to bruise or bleed easily.

Possible Drug Interactions Duloxetine (Cymbalta, Irenka, Yentreve)

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with duloxetine and cause a serious condition called serotonin syndrome.

Many drugs can affect duloxetine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Ordering Duloxetine (Cymbalta, Irenka, Yentreve) from

Ordering discount Duloxetine (Cymbalta, Irenka, Yentreve) online is easy, just contact our team of professional Patient Service Representatives at 1-833-313-3173.

Notice: The information provided above is for informational purposes only. It is not professional medical advice, diagnosis, treatment or care, nor is it intended to be a substitute therefore. Talk to your healthcare professional before following any medical regimen to see if it is safe and effective for you.

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